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细胞法检测酶替代疗法中细胞吸收的抗体

JoVE 신문
면역학 및 감염병학

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JoVE 신문 면역학 및 감염병학

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

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细胞法检测酶替代疗法中细胞吸收的抗体

8,498 Views

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07:52 min

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September 10, 2018

DOI:

10.3791/57777-v

DOI:

10.3791/57777-v

•

07:52 min

September 10, 2018

•

5 Views

Ruby Cheung¹, Gregory W. deHart¹, Lynne Jesaitis¹, Stephen J. Zoog¹, Andrew C. Melton¹

¹BioMarin Pharmaceutical Inc

Summary

在这里, 我们提出了一种基于细胞的流式细胞仪方法来检测中和抗体或其他因素, 干扰细胞吸收酶替代疗法在人类基质, 如脑脊髓液 (CSF) 或人血清。

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