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JoVE Journal Neuroscience
Optogenetic meevoeren van Hippocampal Theta oscillaties in het gedrag van muizen
 
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Optogenetic meevoeren van Hippocampal Theta oscillaties in het gedrag van muizen

Article DOI: 10.3791/57349-v • 07:33 min • June 29th, 2018
June 29th, 2018 •
1,2, 2,3, 1,2
1Systems Neurophysiology Research Group, Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 2Behavioural Neurodynamics Group, Leibniz Institute for Molecular Pharmacology (FMP)/ NeuroCure Cluster of Excellence, 3Neuronal Circuits and Behavior Research Group, Max Planck Institute for Metabolism Research

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We beschrijven het gebruik van optogenetics en elektrofysiologische opnames voor selectieve manipulaties van hippocampal theta oscillaties (5-10 Hz) in gedragend muizen. De werkzaamheid van de entrainment ritme wordt gecontroleerd met behulp van lokale veld potentieel. Een combinatie van opto- en Farmacogenetische inhibitie adressen de efferent uitlezing van hippocampal synchronisatie.

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Neurowetenschappen kwestie 136 Optogenetics elektrofysiologische opnamen in vivo gedrag theta trilling hippocampus piramidale cellen interneuronen septum motoriek farmacogenetica
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