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Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
Chapters
- 00:04Title
- 01:05Culture of Human Induced Pluripotent Stem Cells
- 03:39Differentiation of Human iPSCs to Hepatocyte-like Cells and Small Molecule Screening
- 09:34Results: Differentiation of iPSCs and Identification of Small Molecules for Drug Discovery
- 11:12Conclusion
The protocol presented here describes a platform for identifying small molecules for the treatment of liver disease. A step-by-step description is presented detailing how to differentiate iPSCs into cells with hepatocyte characteristics in 96-well plates, and to use the cells to screen for small molecules with potential therapeutic activity.
