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抗有丝分裂药物多西紫杉醇的前列腺癌细胞模型的建立

JoVE 신문
암 연구학

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JoVE 신문 암 연구학

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

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抗有丝分裂药物多西紫杉醇的前列腺癌细胞模型的建立

12,825 Views

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06:44 min

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September 08, 2017

DOI:

10.3791/56327-v

DOI:

10.3791/56327-v

•

06:44 min

September 08, 2017

•

20 Views

Lisa Mohr¹, Marc Carceles-Cordon¹, Jungreem Woo¹, Carlos Cordon-Cardo¹, Josep Domingo-Domenech¹, Veronica Rodriguez-Bravo^1,2

¹Department of Pathology, Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai, ²Department of Oncological Sciences, Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai

Summary

抗肿瘤治疗有助于疾病的进展和死亡。确定阻力的机械基础对于改善治疗反应是至关重要的。这份手稿详细的协议, 以产生紫杉抗性细胞模型的前列腺癌 (pc), 以帮助解剖的路径涉及的进展, 多西紫杉醇耐药性的 pc 患者。

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