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Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
JoVE Journal
Kanser Araştırmaları
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JoVE Journal Kanser Araştırmaları
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

12,817 Views

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06:44 min

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September 08, 2017

DOI:

10.3791/56327-v

DOI:
10.3791/56327-v

•

06:44 min
September 08, 2017

•

20 Views
, , , , ,
1Department of Pathology, Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai, 2Department of Oncological Sciences, Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai

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Resistance to cancer therapies contributes to disease progression and death. Determining the mechanistic underpinnings of resistance is crucial for improving therapeutic response. This manuscript details the protocol to generate taxane-resistant cell models of prostate cancer (PC) to help dissecting the pathways involved in progression to Docetaxel resistance in PC patients.

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Mohr, L., Carceles-Cordon, M., Woo, J., Cordon-Cardo, C., Domingo-Domenech, J., Rodriguez-Bravo, V. Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel. J. Vis. Exp. (127), e56327, doi:10.3791/56327 (2017).

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