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Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
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Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

15,335 Views

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10:33 min

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September 04, 2017

DOI:

10.3791/56245-v

DOI:
10.3791/56245-v

•

10:33 min
September 04, 2017

•

8 Views
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1CytoGnomix Inc., 2Department of Pathology and Laboratory Medicine,Western University, 3Department of Biochemistry,Western University

Summary

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The cytogenetic dicentric chromosome (DC) assay quantifies exposure to ionizing radiation. The Automated Dicentric Chromosome Identifier and Dose Estimator software accurately and rapidly estimates biological dose from DCs in metaphase cells. It distinguishes monocentric chromosomes and other objects from DCs, and estimates biological radiation dose from the frequency of DCs.

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Cite this Article

Shirley, B., Li, Y., Knoll, J. H., Rogan, P. K. Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation. J. Vis. Exp. (127), e56245, doi:10.3791/56245 (2017).

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