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JoVE Journal Neuroscience
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
 

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Article DOI: 10.3791/55595-v • 07:41 min • June 5th, 2017
June 5th, 2017 •
1,2,3, 2, 2,4, 1,2,3
1Center for Neuroscience, University of Pittsburgh, 2Department of Physical Medicine & Rehabilitation, University of Pittsburgh, School of Medicine, 3Safar Center for Resuscitation Research, University of Pittsburgh, 4Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University

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요약
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Fast-scan cyclic voltammetry can monitor in vivo dopamine neurotransmission in the context of drugs, disease, and other experimental manipulations. This work describes the implementation of QNsim1.0, a software to model electrically stimulated dopamine responses according to the quantitative neurobiological model to quantify estimates of dopamine release and reuptake dynamics.

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Modeling Fast-scan Cyclic Voltammetry Electrically Stimulated Dopamine Neurotransmission QNsim1.0 Kinetics Estimation Dopamine Neurotransmission Study Designs Drugs Disease States User-friendly Platform Experimental Voltammetry Data Quantitative Neurobiological Framework Download Unzip Spreadsheet Organization Dopamine Response Data Micromolar Dopamine Concentration Programming Software QNsim1.0 Directory Initialization.m File New Project Dopamine Data File Dorsal
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