Solvent bonding is a simple and versatile method for fabricating thermoplastic microfluidic devices with high quality bonds. We describe a protocol to achieve strong, optically clear bonds in PMMA and COP microfluidic devices that preserve microfeature details, by a judicious combination of pressure, temperature, an appropriate solvent, and device geometry.
Wan, A. M. D., Moore, T. A., Young, E. W. K. Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices. J. Vis. Exp. (119), e55175, doi:10.3791/55175 (2017).