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Cancer Research
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JoVE Journal Cancer Research
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
 

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Article DOI: 10.3791/54760-v • 06:32 min • October 24th, 2016
October 24th, 2016 •
1, 2, 3, 2, 4,5, 2,3
1Clinic for Surgery and Small Animals, Veterinary Faculty, University of Ljubljana, 2Department of Experimental Oncology, Institute of Oncology Ljubljana, 3Faculty of Health Sciences, University of Primorska, 4IPBS (Institut de Pharmacologie et de Biologie Structurale), CNRS, 5IPBS (Institut de Pharmacologie et de Biologie Structurale), Université de Toulouse

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요약
Automatic Translation

Electrochemotherapy is the local treatment of solid tumors. The main mechanism is electroporation-mediated permeabilization of the tumor cells' membrane which enables increased internalization of cytostatics like bleomycin and cisplatin. Thus, antitumor effectiveness is potentiated at the site of the application of electric pulses to the tumors.

Tags

Electrochemotherapy Tumor Treatment Dogs And Cats Cytostatic Drugs Electric Pulses Cell Membrane Permeabilization Electroporation Chemotherapeutic Drugs Bleomycin Cisplatin Mast Cell Tumor Intratumoral Administration Intravenous Administration Systemic Side Effects Electric Pulse Generator
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