We describe here a transgenic reporter mouse model to visualize the IL-22-producing cells inside different mouse tissues. This method can be used to track the location of other cytokines or secretary proteins in the mouse.
Shen, W., Li, W., Hixon, J. A., Andrews, C., Durum, S. K. Visualization of IL-22-expressing Lymphocytes Using Reporter Mice. J. Vis. Exp. (119), e54710, doi:10.3791/54710 (2017).