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啮齿动物脑显微注射学习动机行为的分子基板
JoVE 신문
행동분석학
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JoVE 신문 행동분석학
Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
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啮齿动物脑显微注射学习动机行为的分子基板

13,983 Views

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10:05 min

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September 16, 2015

DOI:

10.3791/53018-v

DOI:
10.3791/53018-v

•

10:05 min
September 16, 2015

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1 Views
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1Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry,Virginia Commonwealth University School of Medicine, 2Institute for Drug and Alcohol Studies, Departments of Psychiatry, Pharmacology, and Neuroscience,Virginia Commonwealth University School of Medicine

Summary

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Rodents are an appropriate model to investigate the molecular substrates of behavior and complex psychiatric disorders. Brain microinjection in awake rodents can be used to elucidate disease substrates. An efficient and customizable brain microinjection method as well as the execution of an operant paradigm that quantifies motivation is presented.

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Poland, R. S., Bull, C., Syed, W. A., Bowers, M. S. Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior. J. Vis. Exp. (103), e53018, doi:10.3791/53018 (2015).

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