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Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
JoVE Journal
Behavior
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JoVE Journal Behavior
Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

English

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14,019 Views

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10:05 min

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September 16, 2015

DOI:

10.3791/53018-v

DOI:
10.3791/53018-v

•

10:05 min
September 16, 2015

•

1 Views
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1Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry,Virginia Commonwealth University School of Medicine, 2Institute for Drug and Alcohol Studies, Departments of Psychiatry, Pharmacology, and Neuroscience,Virginia Commonwealth University School of Medicine

Summary

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Rodents are an appropriate model to investigate the molecular substrates of behavior and complex psychiatric disorders. Brain microinjection in awake rodents can be used to elucidate disease substrates. An efficient and customizable brain microinjection method as well as the execution of an operant paradigm that quantifies motivation is presented.

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Poland, R. S., Bull, C., Syed, W. A., Bowers, M. S. Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior. J. Vis. Exp. (103), e53018, doi:10.3791/53018 (2015).

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