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Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles
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September 25, 2015
DOI:
1Department of Neurology,The Ohio State University Wexner Medical Center, 2Department of Physical Medicine and Rehabilitation,The Ohio State University, 3Department of Neuroscience,The Ohio State University Wexner Medical Center, 4Department of Biochemistry and Pharmacology,The Ohio State University Wexner Medical Center
Summary
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We present refined protocols that allow in vivo monitoring of motor unit function in the mouse. Techniques to measure compound muscle action potential (CMAP) and motor unit number estimation (MUNE) in the mouse hind limb muscles innervated by the sciatic nerve are described.
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Arnold, W. D., Sheth, K. A., Wier, C. G., Kissel, J. T., Burghes, A. H., Kolb, S. J. Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles. J. Vis. Exp. (103), e52899, doi:10.3791/52899 (2015).
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