JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
Methods to Characterize Spontaneous and Startle-induced Locomotion in a Rotenone-induced Parkinson’s Disease Model of Drosophila
Chapters
- 00:05Title
- 01:12Startle-induced Locomotion Assay and Setup
- 03:11Startle-induced Locomotion Experimentation and Data Analysis
- 04:04Spontaneous Locomotion Assay Setup
- 05:19Spontaneous Locomotion Data Collection and Analysis
- 06:36Results: Rotenone-induced Response Deficiency
- 07:35Conclusion
Parkinson’s disease is a neurodegenerative disorder that results from the degeneration of dopaminergic neurons in the central nervous system, causing locomotion defects. Rotenone models Parkinson’s disease in Drosophila. This paper outlines two assays that characterize both spontaneous and startle-induced locomotion deficiencies caused by rotenone.
