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Neuroscience

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JoVE Journal Neuroscience
Methods to Characterize Spontaneous and Startle-induced Locomotion in a Rotenone-induced Parkinson's Disease Model of Drosophila
 

Methods to Characterize Spontaneous and Startle-induced Locomotion in a Rotenone-induced Parkinson's Disease Model of Drosophila

Article DOI: 10.3791/51625-v • 07:58 min • August 17th, 2014
August 17th, 2014 •
1, 1, 1
1Department of Biology, Colby College

Kapitel

Summary
Automatic Translation

Parkinson’s disease is a neurodegenerative disorder that results from the degeneration of dopaminergic neurons in the central nervous system, causing locomotion defects. Rotenone models Parkinson’s disease in Drosophila. This paper outlines two assays that characterize both spontaneous and startle-induced locomotion deficiencies caused by rotenone.

Tags

Keywords: Parkinson's Disease Drosophila Rotenone Locomotion Startle Response Spontaneous Movement Motor Deficiencies Neurodegenerative Disorder Dopaminergic Neurons Oxidative Damage Mitochondria Negative Geotactic Response High-throughput Assays
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