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Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
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Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

80,060 Views

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08:03 min

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April 15, 2014

DOI:

10.3791/51275-v

DOI:
10.3791/51275-v

•

08:03 min
April 15, 2014

•

56 Views
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1Department of Neurology,University of Münster, 2Interdisciplinary Center for Clinical Research (IZKF), Münster, 3Institute of Physiology – Neuropathophysiology,University of Münster

Summary

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Experimental autoimmune encephalomyelitis (EAE) is an established animal model of multiple sclerosis. C57BL/6 mice are immunized with myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 (MOG35-55), resulting in an ascending flaccid paralysis caused by autoreactive immune cells in the central nervous system. Protocols for disease induction and monitoring will be discussed.

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Experimental Autoimmune EncephalomyelitisEAEMultiple SclerosisMOG35-55C57BL/6 MiceNeuroinflammationDemyelinationAutoimmunityAnimal Model

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Cite this Article

Bittner, S., Afzali, A. M., Wiendl, H., Meuth, S. G. Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice. J. Vis. Exp. (86), e51275, doi:10.3791/51275 (2014).

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