A guided material screening approach to develop sol-gel derived protein doped microarrays using an emerging pin-printing method of fabrication is described. This methodology is demonstrated through the development of acetylcholinesterase and multikinase microarrays, which are used for cost-effective small-molecule screening.
Helka, B., Brennan, J. D. A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays. J. Vis. Exp. (78), e50689, doi:10.3791/50689 (2013).