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Journal / Medicine / A Novel High-resolution In vivo Imaging Technique …
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A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
 

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

Article DOI: 10.3791/50363-v • 12:09 min • June 16th, 2013
June 16th, 2013 •
1, 1, 2, 2, 2, 3
1Brain Tumor Research Centre, Hospital for Sick Children, Toronto Medical Discovery Tower, 2Ontario Cancer Institute, Princess Margaret Hospital, 3Neurosurgery, Toronto Western Hospital

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요약
Automatic Translation

We describe a novel in vivo imaging technique that couples fluorescent chimeric mice with intracranial windows and high-resolution 2-photon microscopy. This imaging platform aids studies of dynamic changes in brain tissue and microvasculature, at a single-cell level, following pathological insults and is adaptable to assess intracranial drug delivery and distribution.

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High-resolution In Vivo Imaging Technique Study Dynamic Response Intracranial Structures Tumor Growth Therapeutics Intracranial Window (ICW) Technology Intravital 2-photon Confocal Microscopy Long-term Visualization Tissue Structure Changes Single Cell Resolution Real-time Fashion End-point Histological Analysis Fluorescent Chimeric Mice Fluorescent Channels Fluorescently Labeled Cells GFP+ Bone Marrow Migration Integration Differentiation Tissue Secondary Reporter Cell MCherry Glioma Tumor Line Cell:cell Interactions Tissue Microenvironment Intra-vital Dyes And Antibodies CD31 Tagged Antibodies Dextran Molecules. Small Animal Micro-irradiator Stereotactic Irradiation
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