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Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior
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Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior

Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior

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12:20 min

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June 10, 2013

DOI:

10.3791/50336-v

DOI:
10.3791/50336-v

•

12:20 min
June 10, 2013

•

7 Views
, , , , , , ,
1Department of Oral and Maxillofacial Surgery,University of Florida College of Dentistry, 2Department of Neuroscience, McKnight Brain Institute,University of Florida College of Medicine , 3Stoelting Co., 4Department of Orthodontics,University of Florida

Summary

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We present a user-friendly, high-throughput operant system for the evaluation of pain behaviors in awake, conscious rodents. The Orofacial Pain Assessment Device (OPAD) can assess pain through a reward/conflict paradigm thus providing a more humane way of testing. This protocol will yield more clinically relevant and translational data from rodents.

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Anderson, E. M., Mills, R., Nolan, T. A., Jenkins, A. C., Mustafa, G., Lloyd, C., Caudle, R. M., Neubert, J. K. Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior. J. Vis. Exp. (76), e50336, doi:10.3791/50336 (2013).

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