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Fluido laterale Percussioni: Modello delle lesioni cerebrali traumatiche nei topi
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August 22, 2011
DOI:
1Department of Neuroscience and Cell Biology,University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 2Spinal Cord and Brain Injury Research Center, 3Department of Anatomy and Neurobiology, Department of Physical Medicine and Rehabilitation,University of Kentucky Chandler Medical Center
Summary
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Laterale fluido percussioni (LFP), un modello stabilito di lesioni cerebrali traumatiche nei topi, è dimostrato. LFP soddisfa tre criteri principali per i modelli animali: rilevanza validità, l'affidabilità e la clinica. La procedura, che consiste di craniotomia chirurgica, la fissazione del mozzo seguita da induzione di lesioni, con conseguente lesioni focali e diffuse, è descritto.
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Alder, J., Fujioka, W., Lifshitz, J., Crockett, D. P., Thakker-Varia, S. Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice. J. Vis. Exp. (54), e3063, doi:10.3791/3063 (2011).
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