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Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
1Department of Neuroscience and Cell Biology,University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 2Spinal Cord and Brain Injury Research Center, 3Department of Anatomy and Neurobiology, Department of Physical Medicine and Rehabilitation,University of Kentucky Chandler Medical Center
Chapters
- 00:05Title
- 01:23Craniectomy
- 05:46Induction of Injury
- 08:19Cognitive, Motor and Histological Outcomes
Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.
Tags
Lateral Fluid PercussionTraumatic Brain InjuryTBI ResearchHead InjuriesMorbidityMortalityPrimary InjurySecondary ConsequencesRegenerative ProcessesContusionSkull FractureShearingStretchingDisplacement Of BrainHematomasLacerationsVascular ResponseWhite Matter DamageDiffuse Axonal InjuryEdemaIncreased Intracranial PressureMicroscopic AlterationsExcitotoxic NeurotransmittersImmune MediatorsOxygen RadicalsLong-term Neurological DisabilitiesAnimal Models Of TBICellular EventsMolecular Events
