A straight-forward and robust method to identify potential regulatory motifs in co-regulated genes is presented. SCOPE does not require any user parameters and returns motifs that represent excellent candidates for regulatory signals. The identification of such regulatory signals helps to understand the underlying biology.
Martyanov, V., Gross, R. H. Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes. J. Vis. Exp. (51), e2703, doi:10.3791/2703 (2011).