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Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
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May 12, 2011
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Optic Nerve transection is a widely used model of adult CNS injury. This model is ideal for performing a number of experimental manipulations that target the retina globally or directly target the injured neuronal population of retinal ganglion cells.
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Optic Nerve TransectionExperimental ManipulationsMammalian CNSRetinal Ganglion CellsOptic NerveAxotomizedApoptotic Neuronal Cell DeathVitreous ChamberDrug DeliveryIntraocular InjectionsViral VectorsPlasmidsSiRNAsAdeno-Associated Virus (AAV) VectorsRGCs TargetingSuperior ColliculusApoptotic Mechanisms
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D'Onofrio, P. M., Magharious, M. M., Koeberle, P. D. Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS. J. Vis. Exp. (51), e2261, doi:10.3791/2261 (2011).
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