17.12:

Golgi Apparatus

JoVE 핵심
Cell Biology
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다.  전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
JoVE 핵심 Cell Biology
Golgi Apparatus

7,728 Views

01:09 min

April 30, 2023

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.

The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are transported through a stack of membrane-enclosed cisternae. Each cisterna contains unique compositions of enzymes and performs specific protein modifications, such as phosphorylation and glycosylation. After modifications in the trans cisterna, proteins are given tags that define their cellular destination.

Depending on the molecular tags, proteins are packaged into vesicles and trafficked to particular cellular locations, such as the plasma membrane. Specific markers on the membranes of these vesicles allow them to dock at the appropriate cellular location.