JOVE JOURNAL

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Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Varone Antonio¹, Adya Panchal², Magdalena Kasendra³, Barrile Riccardo^2,3

¹Merk Sharp & Dohme LLC, ²Department of Biomedical Engineering,University of Cincinnati, ³Center for Stem Cell and Organoid Medicine,Cincinnati Children's Hospital Medical Center

Journal (Bioengineering)

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Griffin Mess^1,2, Taylor Anderson^1,2, Shivani Kapoor³, Rasika Thombre^1,2, Ruixing Liang⁴, Emre Derin¹, Kelley M. Kempski-Leadingham¹, Santosh K. Yadav⁵, Betty Tyler¹, Amir Manbachi^1,2,4,6,7

¹Department of Neurosurgery,Johns Hopkins University School of Medicine, ²Department of Biomedical Engineering,Johns Hopkins University, ³Krieger School of Arts and Sciences,Johns Hopkins University, ⁴Department of Electrical Engineering and Computer Science,Johns Hopkins University, ⁵Department of Radiology, Cancer Imaging Division,Johns Hopkins University School of Medicine, ⁶Department of Mechanical Engineering,Johns Hopkins University, ⁷Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University School of Medicine

Journal (Bioengineering)

Three-Dimensional Culture of Vascularized Thermogenic Adipose Tissue from Microvascular Fragments

Francisca M. Acosta¹, Maria A. Gonzalez Porras^2,3, Katerina Stojkova², Settimio Pacelli², Christopher R. Rathbone^2,3, Eric M. Brey^2,3

¹Department of Biochemistry and Structural Biology,University of Texas Health Science Center, ²Department of Biomedical Engineering and Chemical Engineering,University of Texas at San Antonio, ³Institute of Regenerative Medicine,University of Texas at San Antonio

Journal (Bioengineering)

Setup of Consumer Wearable Devices for Exposure and Health Monitoring in Population Studies

Antonis Michanikou¹, Panayiotis Kouis¹, Kostas Karanicolas¹, Panayiotis K. Yiallouros¹

¹Respiratory Physiology Laboratory, Medical School,University of Cyprus

Journal (Bioengineering)

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Anne-Kathrin Schott¹, Ivan Zipančić², Vicente Hernández-Rabaza², Zorica A. Becker-Kojić¹

¹ACA CELL Biotech GmbH, ²Departamento Ciencias Biomédicas,Universidad Cardenal Herrera-CEU

Journal (Bioengineering)

Automation of the Micronucleus Assay Using Imaging Flow Cytometry and Artificial Intelligence

Matthew A. Rodrigues¹, María Gracia García Mendoza¹, Raymond Kong¹, Alexandra Sutton¹, Haley R. Pugsley¹, Yang Li¹, Brian E. Hall¹, Darin Fogg¹, Lars Ohl¹, Vidya Venkatachalam¹

¹Amnis Flow Cytometry,Luminex Corporation

Journal (Bioengineering)

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Meagan J. Makarcyzk^1,2, Zhong Alan Li^1,3, Ilhan Yu¹, Haruyo Yagi¹, Xiurui Zhang¹, Lauren Yocum¹, Eileen Li¹, Madalyn R. Fritch¹, Qi Gao⁴, Bruce A. Bunnell⁵, Stuart B. Goodman^4,6, Rocky S. Tuan^1,8, Peter G. Alexander^1,7, Hang Lin^1,2,7

¹Department of Orthopaedic Surgery,University of Pittsburgh School of Medicine, ²Department of Bioengineering,University of Pittsburgh Swanson School of Engineering, ³Department of Neurobiology,University of Pittsburgh School of Medicine, ⁴Department of Orthopaedic Surgery,Stanford University, ⁵Department of Microbiology, Immunology, and Genetics,University of North Texas Health Science Center, ⁶Department of Bioengineering,Stanford University, ⁷McGowan Institute for Regenerative Medicine,University of Pittsburgh School of Medicine, ⁸The Chinese University of Hong Kong

Journal (Bioengineering)

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Nicolas Werschler^1,2, Josef Penninger^1,2,3,4

¹School of Biomedical Engineering,University of British Columbia, ²Life Sciences Institute,University of British Columbia, ³Department of Medical Genetics,University of British Columbia, ⁴Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)

Journal (Bioengineering)

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing

Rakan El-Mayta¹, Marshall S. Padilla¹, Margaret M. Billingsley¹, Xuexiang Han¹, Michael J. Mitchell¹

¹Department of Bioengineering,University of Pennsylvania

Journal (Bioengineering)

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System

Fernando Bladimir Valdivieso-Rivera*¹, Vanessa de Oliveira Furino*¹, Carlos Henrique Sponton^1,2

¹Obesity and Comorbidities Research Center,State University of Campinas, ²Department of Structural and Functional Biology, Institute of Biology,State University of Campinas

Journal (Bioengineering)

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Utku M. Sönmez¹, Nolan Frey², Jonathan S. Minden², Philip R. LeDuc¹

¹Department of Mechanical Engineering,Carnegie Mellon University, ²Department of Biological Sciences,Carnegie Mellon University

Journal (Bioengineering)

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes

Tromondae K. Feaster¹, Maura Casciola¹, Akshay Narkar¹, Ksenia Blinova¹

¹Office of Science and Engineering Laboratories, Center for Devices and Radiological Health,U.S. Food and Drug Administration

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