Sex-Specific Glial Biomarkers in Alzheimer's Disease: A Transcriptome Analysis

May 20, 2024

基于神经胶质转录组谱的阿尔茨海默病性别特异性生物标志物鉴定

鉴定阿尔茨海默病中性别特异性的神经胶质细胞生物标志物

Hanjie Liu*¹, Hui Yang*², Shuqing Liu, Siyu Li, Wen Yang, Anwar Ayesha, Xin Tan, Cen Jiang, Yi Liu, Lushuang Xie

¹Chengdu University of Traditional Chinese Medicine, ²Chengdu Shuangliu Hospital of Traditional Chinese Medicine, ³Department of Automation,Tsinghua University, ⁴Affiliated Reproductive & Women-Children Hospital,Chengdu University of Traditional Chinese Medicine, ⁵Department of Neurology, Dalian Municipal Central Hospital,Central Hospital of Dalian University of Technology

Summary

这项研究分析了 33 名阿尔茨海默病（AD）患者的单核转录组，揭示了神经胶质细胞中的性别特异性 DEG。功能富集分析突出了突触、神经和激素相关通路。确定了关键基因，即NLGN4Y及其调控因子，并提出了性别特异性AD的潜在治疗候选药物。

Article