Weiping Zou Department of Surgery University of Michigan Biography Publications Institution JoVE Articles Weiping Zou has not added a biography. If you are Weiping Zou and would like to personalize this page please email our Author Liaison for assistance. Publications Mathematical Modeling of the Metastatic Colorectal Cancer Microenvironment Defines the Importance of Cytotoxic Lymphocyte Infiltration and Presence of PD-L1 on Antigen Presenting Cells Annals of Surgical Oncology. Jun, 2019 | Pubmed ID: 31250346 Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy Cancer Research. May, 2019 | Pubmed ID: 31101760 Immunotherapy in Ovarian Cancer Surgical Oncology Clinics of North America. Jul, 2019 | Pubmed ID: 31079799 RORγ Agonists Enhance the Sustained Antitumor Activity Through Intrinsic Tc17 Cytotoxicity and Tc1 Recruitment Cancer Immunology Research. Jul, 2019 | Pubmed ID: 31064778 CD8 T Cells Regulate Tumour Ferroptosis During Cancer Immunotherapy Nature. May, 2019 | Pubmed ID: 31043744 CD4+ Tissue-resident Memory T Cells Expand and Are a Major Source of Mucosal Tumour Necrosis Factor α in Active Crohn's Disease Journal of Crohn's & Colitis. Jul, 2019 | Pubmed ID: 30715262 Tracking Macrophage Infiltration in a Mouse Model of Pancreatic Cancer with the Positron Emission Tomography Tracer [11C]PBR28 The Journal of Surgical Research. 12, 2018 | Pubmed ID: 30463776 Spatial and Phenotypic Immune Profiling of Metastatic Colon Cancer JCI Insight. 11, 2018 | Pubmed ID: 30429368 Tumor-infiltrating T Cells in Epithelial Ovarian Cancer: Predictors of Prognosis and Biological Basis of Immunotherapy Gynecologic Oncology. 10, 2018 | Pubmed ID: 30243508 Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer Cell. 06, 2018 | Pubmed ID: 29906450 Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity Via a Specific CEBPB Isoform in Triple-Negative Breast Cancer Cell Metabolism. Jul, 2018 | Pubmed ID: 29805099 Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis Journal of Immunology (Baltimore, Md. : 1950). 07, 2018 | Pubmed ID: 29802127 Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness Cancer Research. Jul, 2018 | Pubmed ID: 29769201 Understanding the Tumor Immune Microenvironment (TIME) for Effective Therapy Nature Medicine. 05, 2018 | Pubmed ID: 29686425 Mechanistic Insights into Cancer Immunity and Immunotherapy Cellular & Molecular Immunology. May, 2018 | Pubmed ID: 29572549 MiR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Cancer Research. 04, 2018 | Pubmed ID: 29374066 Host Expression of PD-L1 Determines Efficacy of PD-L1 Pathway Blockade-mediated Tumor Regression The Journal of Clinical Investigation. 02, 2018 | Pubmed ID: 29337305 The Role of Tumor Microenvironment in Cancer Immunotherapy Advances in Experimental Medicine and Biology. 2017 | Pubmed ID: 29275464 Phenotype and Tissue Distribution of CD28H Immune Cell Subsets Oncoimmunology. 2017 | Pubmed ID: 29209568 Suppression of FIP200 and Autophagy by Tumor-derived Lactate Promotes Naïve T Cell Apoptosis and Affects Tumor Immunity Science Immunology. 11, 2017 | Pubmed ID: 29150439 Hepatic Neuregulin 4 Signaling Defines an Endocrine Checkpoint for Steatosis-to-NASH Progression The Journal of Clinical Investigation. 12, 2017 | Pubmed ID: 29106384 Oxidative Stress Controls Regulatory T Cell Apoptosis and Suppressor Activity and PD-L1-blockade Resistance in Tumor Nature Immunology. Dec, 2017 | Pubmed ID: 29083399 Fusobacterium Nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy Cell. Jul, 2017 | Pubmed ID: 28753429 ARID1A-mutated Ovarian Cancers Depend on HDAC6 activity Nature Cell Biology. 08, 2017 | Pubmed ID: 28737768 Chemokines in the Cancer Microenvironment and Their Relevance in Cancer Immunotherapy Nature Reviews. Immunology. Sep, 2017 | Pubmed ID: 28555670 IL33 Promotes Colon Cancer Cell Stemness Via JNK Activation and Macrophage Recruitment Cancer Research. 05, 2017 | Pubmed ID: 28249897 Synthetic RORγ Agonists Regulate Multiple Pathways to Enhance Antitumor Immunity Oncoimmunology. 2016 | Pubmed ID: 28123897 Inflammatory Regulatory T Cells in the Microenvironments of Ulcerative Colitis and Colon Carcinoma Oncoimmunology. Aug, 2016 | Pubmed ID: 27622054 Th22 Cells Control Colon Tumorigenesis Through STAT3 and Polycomb Repression Complex 2 Signaling Oncoimmunology. Aug, 2016 | Pubmed ID: 27622053 Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells Through IL6/STAT3 and NO/NOTCH Cross-talk Signaling Cancer Research. 06, 2016 | Pubmed ID: 27197152 LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act As a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern Cancer Discovery. 07, 2016 | Pubmed ID: 27147598 Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer Cell. May, 2016 | Pubmed ID: 27133165 Hydrogel Dual Delivered Celecoxib and Anti-PD-1 Synergistically Improve Antitumor Immunity Oncoimmunology. Feb, 2016 | Pubmed ID: 27057439 PD-L1 (B7-H1) and PD-1 Pathway Blockade for Cancer Therapy: Mechanisms, Response Biomarkers, and Combinations Science Translational Medicine. Mar, 2016 | Pubmed ID: 26936508 Biological and Pathological Activities of Interleukin-22 Journal of Molecular Medicine (Berlin, Germany). 05, 2016 | Pubmed ID: 26923718 PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer Cancer Research. Jan, 2016 | Pubmed ID: 26567139 Cancer Mediates Effector T Cell Dysfunction by Targeting MicroRNAs and EZH2 Via Glycolysis Restriction Nature Immunology. Jan, 2016 | Pubmed ID: 26523864 Epigenetic Silencing of TH1-type Chemokines Shapes Tumour Immunity and Immunotherapy Nature. Nov, 2015 | Pubmed ID: 26503055 Chemokines and Cellular Plasticity of Ovarian Cancer Stem Cells Oncoscience. 2015 | Pubmed ID: 26328269 Dendritic Cells Are Stressed out in Tumor Cell Research. Sep, 2015 | Pubmed ID: 26227962 Consensus Nomenclature for CD8+ T Cell Phenotypes in Cancer Oncoimmunology. Apr, 2015 | Pubmed ID: 26137416 Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies Cancer Immunology Research. Nov, 2015 | Pubmed ID: 26025381 Myeloid Cells in Hepatocellular Carcinoma Hepatology (Baltimore, Md.). Oct, 2015 | Pubmed ID: 25914264 OCT1 is a Determinant of Synbindin-related ERK Signalling with Independent Prognostic Significance in Gastric Cancer Gut. Jan, 2015 | Pubmed ID: 24717932 Classification of Current Anticancer Immunotherapies Oncotarget. Dec, 2014 | Pubmed ID: 25537519 MiR-194 Deregulation Contributes to Colorectal Carcinogenesis Via Targeting AKT2 Pathway Theranostics. 2014 | Pubmed ID: 25285168 Long Noncoding RNA GAPLINC Regulates CD44-dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer Cancer Research. Dec, 2014 | Pubmed ID: 25277524 Tumor-associated Macrophages Produce Interleukin 6 and Signal Via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells Gastroenterology. Dec, 2014 | Pubmed ID: 25181692 MiR-198 Represses Tumor Growth and Metastasis in Colorectal Cancer by Targeting Fucosyl Transferase 8 Scientific Reports. Sep, 2014 | Pubmed ID: 25174450 ArhGAP30 Promotes P53 Acetylation and Function in Colorectal Cancer Nature Communications. Aug, 2014 | Pubmed ID: 25156493 TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2014 | Pubmed ID: 24987055 IL-22(+)CD4(+) T Cells Promote Colorectal Cancer Stemness Via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L Immunity. May, 2014 | Pubmed ID: 24816405 T Cells and Costimulation in Cancer Cancer Journal (Sudbury, Mass.). Nov-Dec, 2013 | Pubmed ID: 24270346 Synbindin in Extracellular Signal-Regulated Protein Kinase Spatial Regulation and Gastric Cancer Aggressiveness Journal of the National Cancer Institute. Oct, 2013 | Pubmed ID: 24104608 TLR2 Mediates Helicobacter Pylori-induced Tolerogenic Immune Response in Mice PloS One. 2013 | Pubmed ID: 24058595 Myeloid-derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2 Immunity. Sep, 2013 | Pubmed ID: 24012420 NF-κB Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells by Promoting β-catenin Degradation Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23690607 Effects of Tumor Irradiation on Host T-regulatory Cells and Systemic Immunity in the Context of Adoptive T-cell Therapy in Mice Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb, 2013 | Pubmed ID: 23377667 T Cell Anergy, Exhaustion, Senescence, and Stemness in the Tumor Microenvironment Current Opinion in Immunology. Apr, 2013 | Pubmed ID: 23298609 Elevated Serum IL-8 is Associated with the Presence of Hepatocellular Carcinoma and Independently Predicts Survival Cancer Investigation. Dec, 2012 | Pubmed ID: 23072563 Nine Lives for TH9s? Nature Medicine. Aug, 2012 | Pubmed ID: 22869182 Th17 Cells Have Stem Cell-like Features and Promote Long-term Immunity Oncoimmunology. Jul, 2012 | Pubmed ID: 22754771 Regulatory T Cells in the Bone Marrow Microenvironment in Patients with Prostate Cancer Oncoimmunology. Mar, 2012 | Pubmed ID: 22720236 Regulatory T Cells in Human Ovarian Cancer Journal of Oncology. 2012 | Pubmed ID: 22481922 The B7 Homologues and Their Receptors in Hematologic Malignancies European Journal of Haematology. Jun, 2012 | Pubmed ID: 22372959 Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis Cancer Research. Jan, 2012 | Pubmed ID: 22123924 Bone Marrow and the Control of Immunity Cellular & Molecular Immunology. Jan, 2012 | Pubmed ID: 22020068 Expression of Aldehyde Dehydrogenase and CD133 Defines Ovarian Cancer Stem Cells International Journal of Cancer. Journal International Du Cancer. Jan, 2012 | Pubmed ID: 21480217 Endogenous Interleukin-10 Constrains Th17 Cells in Patients with Inflammatory Bowel Disease Journal of Translational Medicine. Dec, 2011 | Pubmed ID: 22176654 Human TH17 Cells Are Long-lived Effector Memory Cells Science Translational Medicine. Oct, 2011 | Pubmed ID: 21998407 Deciphering the Role of Th17 Cells in Human Disease Trends in Immunology. Dec, 2011 | Pubmed ID: 21958759 Dual Biological Effects of the Cytokines Interleukin-10 and Interferon-γ Cancer Immunology, Immunotherapy : CII. Nov, 2011 | Pubmed ID: 21918895 Suppression of Autophagy by FIP200 Deletion Inhibits Mammary Tumorigenesis Genes & Development. Jul, 2011 | Pubmed ID: 21764854 Antigen-presenting Cell (APC) Subsets in Ovarian Cancer International Reviews of Immunology. Apr-Jun, 2011 | Pubmed ID: 21557638 IL-17+ Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21357259 T Lymphocytes to IDO+ Cells: Check Blood. Feb, 2011 | Pubmed ID: 21330479 Th17 Cells in Cancer: Help or Hindrance? Carcinogenesis. May, 2011 | Pubmed ID: 21304053 A Crucial Role for Host APCs in the Induction of Donor CD4+CD25+ Regulatory T Cell-mediated Suppression of Experimental Graft-versus-host Disease Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20810991 Prognostic Significance of Regulatory T Cells in Tumor International Journal of Cancer. Aug, 2010 | Pubmed ID: 20473951 T(H)17 Cells in Tumour Immunity and Immunotherapy Nature Reviews. Immunology. Apr, 2010 | Pubmed ID: 20336152 Helicobacter Pylori Immune Escape is Mediated by Dendritic Cell-induced Treg Skewing and Th17 Suppression in Mice Gastroenterology. Mar, 2010 | Pubmed ID: 19931266 Role of T Cell TGFbeta Signaling and IL-17 in Allograft Acceptance and Fibrosis Associated with Chronic Rejection Journal of Immunology (Baltimore, Md. : 1950). Dec, 2009 | Pubmed ID: 19917689 Modeling Dynamic Changes in Type 1 Diabetes Progression: Quantifying Beta-cell Variation After the Appearance of Islet-specific Autoimmune Responses Mathematical Biosciences and Engineering : MBE. Oct, 2009 | Pubmed ID: 19835428 Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma is Mediated by B7-H1/programmed Death-1 Interactions Cancer Research. Oct, 2009 | Pubmed ID: 19826049 Phenotype, Distribution, Generation, and Functional and Clinical Relevance of Th17 Cells in the Human Tumor Environments Blood. Aug, 2009 | Pubmed ID: 19470694 FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease Cancer Research. May, 2009 | Pubmed ID: 19383912 Endogenous IL-17 Contributes to Reduced Tumor Growth and Metastasis Blood. Jul, 2009 | Pubmed ID: 19289853 Cutting Edge: IFN-gamma Enables APC to Promote Memory Th17 and Abate Th1 Cell Development Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18941172 Induction of IL-17+ T Cell Trafficking and Development by IFN-gamma: Mechanism and Pathological Relevance in Psoriasis Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18802076 Tumor-induced Immune Suppression of in Vivo Effector T-cell Priming is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor Beta Cancer Research. Jul, 2008 | Pubmed ID: 18593946 Inhibitory B7-family Molecules in the Tumour Microenvironment Nature Reviews. Immunology. Jun, 2008 | Pubmed ID: 18500231 Drugs Designed to Inhibit Human P38 Mitogen-activated Protein Kinase Activation Treat Toxoplasma Gondii and Encephalitozoon Cuniculi Infection Antimicrobial Agents and Chemotherapy. Dec, 2007 | Pubmed ID: 17923491 Relationship Between B7-H4, Regulatory T Cells, and Patient Outcome in Human Ovarian Carcinoma Cancer Research. Sep, 2007 | Pubmed ID: 17875732 Interleukin-2 Administration Alters the CD4+FOXP3+ T-cell Pool and Tumor Trafficking in Patients with Ovarian Carcinoma Cancer Research. Aug, 2007 | Pubmed ID: 17671219 Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007 | Pubmed ID: 17513719 Stroma-derived Factor (SDF-1/CXCL12) and Human Tumor Pathogenesis American Journal of Physiology. Cell Physiology. Mar, 2007 | Pubmed ID: 16943240 Cutting Edge: Induction of B7-H4 on APCs Through IL-10: Novel Suppressive Mode for Regulatory T Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16785496 B7-H4 Expression Identifies a Novel Suppressive Macrophage Population in Human Ovarian Carcinoma The Journal of Experimental Medicine. Apr, 2006 | Pubmed ID: 16606666 Regulatory T Cells, Tumour Immunity and Immunotherapy Nature Reviews. Immunology. Apr, 2006 | Pubmed ID: 16557261 Regulatory T-cell Compartmentalization and Trafficking Blood. Jul, 2006 | Pubmed ID: 16537800 Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry Jenny Lazarus1, Yagiz Akiska1, Mirna Perusina Lanfranca1, Lawrence Delrosario1, Lei Sun1, Daniel Long2, Jiaqi Shi3, Howard Crawford2, Marina P. Di Magliano1, Weiping Zou1, Timothy Frankel1 1Department of Surgery, University of Michigan, 2Department of Molecular and Cellular Physiology, University of Michigan, 3Department of Pathology, University of Michigan JoVE 59915 암 연구학
Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry Jenny Lazarus1, Yagiz Akiska1, Mirna Perusina Lanfranca1, Lawrence Delrosario1, Lei Sun1, Daniel Long2, Jiaqi Shi3, Howard Crawford2, Marina P. Di Magliano1, Weiping Zou1, Timothy Frankel1 1Department of Surgery, University of Michigan, 2Department of Molecular and Cellular Physiology, University of Michigan, 3Department of Pathology, University of Michigan JoVE 59915 암 연구학