Alain Baulard

Publications

• Structural and Docking Studies of Potent Ethionamide Boosters
  Acta Crystallographica. Section C, Crystal Structure Communications. Nov, 2013  |   Pubmed ID: 24192167
• Mechanism of Competence Activation by the ComRS Signalling System in Streptococci
  Molecular Microbiology. Mar, 2013  |   Pubmed ID: 23323845
• Discovery of Novel N-phenylphenoxyacetamide Derivatives As EthR Inhibitors and Ethionamide Boosters by Combining High-throughput Screening and Synthesis
  Journal of Medicinal Chemistry. Jul, 2012  |   Pubmed ID: 22738293
• Tuberculosis: the Drug Development Pipeline at a Glance
  European Journal of Medicinal Chemistry. May, 2012  |   Pubmed ID: 22421275
• Structural Activation of the Transcriptional Repressor EthR from Mycobacterium Tuberculosis by Single Amino Acid Change Mimicking Natural and Synthetic Ligands
  Nucleic Acids Research. Apr, 2012  |   Pubmed ID: 22156370
• Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-oxadiazole EthR Inhibitors
  Journal of Medicinal Chemistry. Jan, 2012  |   Pubmed ID: 22098589
• MALDI Imaging Techniques Dedicated to Drug-distribution Studies
  Bioanalysis. Jun, 2011  |   Pubmed ID: 21679033
• Ethionamide Boosters: Synthesis, Biological Activity, and Structure-activity Relationships of a Series of 1,2,4-oxadiazole EthR Inhibitors
  Journal of Medicinal Chemistry. Apr, 2011  |   Pubmed ID: 21417236
• Exploring Drug Target Flexibility Using in Situ Click Chemistry: Application to a Mycobacterial Transcriptional Regulator
  ACS Chemical Biology. Nov, 2010  |   Pubmed ID: 20704273
• Synthetic EthR Inhibitors Boost Antituberculous Activity of Ethionamide
  Nature Medicine. May, 2009  |   Pubmed ID: 19412174
• Molecular Mapping of Lipoarabinomannans on Mycobacteria
  Langmuir : the ACS Journal of Surfaces and Colloids. Apr, 2009  |   Pubmed ID: 19278203
• Molecular Genetics of Para-aminosalicylic Acid Resistance in Clinical Isolates and Spontaneous Mutants of Mycobacterium Tuberculosis
  Antimicrobial Agents and Chemotherapy. May, 2009  |   Pubmed ID: 19237648
• Organization of the Mycobacterial Cell Wall: a Nanoscale View
  Pflügers Archiv : European Journal of Physiology. Apr, 2008  |   Pubmed ID: 18043940
• Direct Measurement of Hydrophobic Forces on Cell Surfaces Using AFM
  Langmuir : the ACS Journal of Surfaces and Colloids. Nov, 2007  |   Pubmed ID: 17941657
• Antibody Response in Pulmonary Tuberculosis Against Recombinant 27kDa (MPT51, Rv3803c) Protein of Mycobacterium Tuberculosis
  Scandinavian Journal of Infectious Diseases. 2007  |   Pubmed ID: 17852894
• Chemical Force Microscopy of Single Live Cells
  Nano Letters. Oct, 2007  |   Pubmed ID: 17850167
• Ethambutol-induced Alterations in Mycobacterium Bovis BCG Imaged by Atomic Force Microscopy
  FEMS Microbiology Letters. Nov, 2006  |   Pubmed ID: 17064372
• Selective Intracellular Accumulation of the Major Metabolite Issued from the Activation of the Prodrug Ethionamide in Mycobacteria
  The Journal of Antimicrobial Chemotherapy. Oct, 2006  |   Pubmed ID: 16895935
• Insights into Mechanisms of Induction and Ligands Recognition in the Transcriptional Repressor EthR from Mycobacterium Tuberculosis
  Tuberculosis (Edinburgh, Scotland). Mar, 2006  |   Pubmed ID: 16243584
• Monitoring of the Ethionamide Pro-drug Activation in Mycobacteria by (1)H High Resolution Magic Angle Spinning NMR
  Biochemical and Biophysical Research Communications. Jun, 2005  |   Pubmed ID: 15850780
• [Doping in the Peloton of Antituberculosis Drugs]
  Médecine Sciences : M/S. Apr, 2005  |   Pubmed ID: 15811295
• Structure of EthR in a Ligand Bound Conformation Reveals Therapeutic Perspectives Against Tuberculosis
  Molecular Cell. Oct, 2004  |   Pubmed ID: 15494316
• Cloning, Expression, and Purification of the 27 KDa (MPT51, Rv3803c) Protein of Mycobacterium Tuberculosis
  Protein Expression and Purification. Jul, 2004  |   Pubmed ID: 15177284
• Identification of a Novel Class of Omega,E,E-farnesyl Diphosphate Synthase from Mycobacterium Tuberculosis
  Journal of Lipid Research. Jun, 2004  |   Pubmed ID: 15060088
• EthR, a Repressor of the TetR/CamR Family Implicated in Ethionamide Resistance in Mycobacteria, Octamerizes Cooperatively on Its Operator
  Molecular Microbiology. Jan, 2004  |   Pubmed ID: 14651620
• Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium Tuberculosis
  The Journal of Biological Chemistry. Dec, 2003  |   Pubmed ID: 14559907
• Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria
  The Journal of Biological Chemistry. Jun, 2003  |   Pubmed ID: 12654922
• In Vivo Interaction Between the Polyprenol Phosphate Mannose Synthase Ppm1 and the Integral Membrane Protein Ppm2 from Mycobacterium Smegmatis Revealed by a Bacterial Two-hybrid System
  The Journal of Biological Chemistry. Jan, 2003  |   Pubmed ID: 12427759
• Characterization of a Putative Alpha-mannosyltransferase Involved in Phosphatidylinositol Trimannoside Biosynthesis in Mycobacterium Tuberculosis
  The Biochemical Journal. May, 2002  |   Pubmed ID: 11964144
• Ppm1, a Novel Polyprenol Monophosphomannose Synthase from Mycobacterium Tuberculosis
  The Biochemical Journal. Jul, 2002  |   Pubmed ID: 11931640