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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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JoVE Journal Chemistry
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

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6,827 Views

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09:34 min

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February 06, 2020

DOI:

10.3791/60442-v

DOI:
10.3791/60442-v

•

09:34 min
February 06, 2020

•

4 Views
, ,
1Department of Chemical Engineering,University of Michigan, 2Department of Chemical Engineering,Monash University, 3Department of Materials Science and Engineering,Monash University

Summary

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A protocol is presented for the synthesis of information-encoded peptoid oligomers and for the sequence-directed self-assembly of these peptoids into molecular ladders using amines and aldehydes as dynamic covalent reactant pairs and Lewis acidic rare-earth metal triflates as multi-role reagents.

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PeptoidsDynamic Covalent Self-assemblySequence-directed AssemblyInformation-directed AssemblyLewis AcidKinetic TrappingCovalent Bond RearrangementFMOC Photolabile Solid Support ResinAutomated Peptide SynthesizerPrimary AmineBromoacetic AcidDICAcetic AnhydrideDMFNMP

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Leguizamon, S. C., Alqubati, A. F., Scott, T. F. Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly. J. Vis. Exp. (156), e60442, doi:10.3791/60442 (2020).

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