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Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

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14,188 Views

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10:24 min

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May 15, 2018

DOI:

10.3791/57548-v

DOI:
10.3791/57548-v

•

10:24 min
May 15, 2018

•

21 Views
, ,
1Department of Neuroscience and Brain Technologies,Istituto Italiano di Tecnologia, 2Rehab Technologies,Istituto Italiano di Tecnologia

Summary

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We illustrate how to perform recording and electrical modulation of 4-aminopyridine-induced epileptiform activity in rodent brain slices using microelectrode arrays. A custom recording chamber maintains tissue viability throughout prolonged experimental sessions. Live electrode mapping and selection of stimulating pairs are performed by a custom graphical user interface.

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Cite this Article

Panuccio, G., Colombi, I., Chiappalone, M. Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays. J. Vis. Exp. (135), e57548, doi:10.3791/57548 (2018).

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