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Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis
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神経科学
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JoVE Journal 神経科学
Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

3,507 Views

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08:27 min

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September 02, 2021

DOI:

10.3791/62699-v

DOI:
10.3791/62699-v

•

08:27 min
September 02, 2021

•

7 Views
,
1Geriatrics Research Education and Clinical Center,Veterans Affairs Puget Sound Health Care System, 2Division of Gerontology and Geriatric Medicine, Department of Medicine,University of Washington

概要

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This protocol describes two sensitive assays for discriminating among mild, moderate, and severe motor impairment in C. elegans models of amyotrophic lateral sclerosis, with general utility for C. elegans strains, with altered motility.

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Cite this Article

Currey, H. N., Liachko, N. F. Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis. J. Vis. Exp. (175), e62699, doi:10.3791/62699 (2021).

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