Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Vivek Bhaskaran; Pierpaolo Peruzzi

doi:10.3791/60215

/

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

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JoVE Journal 遺伝学

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

5,507 Views

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09:40 min

•

October 04, 2019

DOI:

10.3791/60215-v

DOI:

10.3791/60215-v

•

09:40 min

October 04, 2019

•

1 Views

Vivek Bhaskaran¹, Pierpaolo Peruzzi¹

¹Department of Neurosurgery,Brigham and Women’s Hospital-Harvard Medical School

概要

Described here is a protocol for characterizing modules of biologically synergistic miRNAs and their assembly into short transgenes, which allows simultaneous overexpression for gene therapy applications.

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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

概要

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