Chronic Salmonella Infection Induced Intestinal Fibrosis

Bernard  C. Lo; Samuel  B. Shin; Melina Messing; Kelly M. McNagny

doi:10.3791/60068

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免疫学と感染

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Chronic Salmonella Infection Induced Intestinal Fibrosis

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免疫学と感染

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JoVE Journal 免疫学と感染

Chronic Salmonella Infection Induced Intestinal Fibrosis

6,634 Views

•

08:40 min

•

September 22, 2019

DOI:

10.3791/60068-v

DOI:

10.3791/60068-v

•

08:40 min

September 22, 2019

•

8 Views

Bernard C. Lo¹, Samuel B. Shin¹, Melina Messing¹, Kelly M. McNagny¹

¹The Biomedical Research Centre,University of British Columbia

概要

This protocol describes a mouse model of Salmonella driven intestinal fibrosis that resembles key pathological hallmarks of Crohn’s disease including transmural inflammation and fibrosis. This method can be used to evaluate host factors that alter fibrotic outcomes using mutant mice maintained on a C57Bl/6 genetic background.

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Chronic Salmonella Infection Induced Intestinal Fibrosis

概要

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