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Chronic Salmonella Infection Induced Intestinal Fibrosis
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September 22, 2019
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This protocol describes a mouse model of Salmonella driven intestinal fibrosis that resembles key pathological hallmarks of Crohn’s disease including transmural inflammation and fibrosis. This method can be used to evaluate host factors that alter fibrotic outcomes using mutant mice maintained on a C57Bl/6 genetic background.
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Lo, B. C., Shin, S. B., Messing, M., McNagny, K. M. Chronic Salmonella Infection Induced Intestinal Fibrosis. J. Vis. Exp. (151), e60068, doi:10.3791/60068 (2019).
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