Here, we present a method for delivering viral expression vectors into the brain using silk fibroin films. This method allows targeted delivery of expression vectors using silk/AAV coated optical fibers, tapered optical fibers, and cranial windows.
Jackman, S. L., Chen, C. H., Regehr, W. G. In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films. J. Vis. Exp. (144), e58728, doi:10.3791/58728 (2019).