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Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
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June 05, 2017
DOI:
1Center for Neuroscience,University of Pittsburgh, 2Department of Physical Medicine & Rehabilitation,University of Pittsburgh, School of Medicine, 3Safar Center for Resuscitation Research,University of Pittsburgh, 4Department of Biological Sciences, Mellon College of Science,Carnegie Mellon University
概要
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Fast-scan cyclic voltammetry can monitor in vivo dopamine neurotransmission in the context of drugs, disease, and other experimental manipulations. This work describes the implementation of QNsim1.0, a software to model electrically stimulated dopamine responses according to the quantitative neurobiological model to quantify estimates of dopamine release and reuptake dynamics.
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Harun, R., Grassi, C. M., Munoz, M. J., Wagner, A. K. Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0. J. Vis. Exp. (124), e55595, doi:10.3791/55595 (2017).
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