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Immunology and Infection

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JoVE Journal Immunology and Infection
A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
 

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Article DOI: 10.3791/64041-v • 08:30 min • September 16th, 2022
September 16th, 2022 •
1,2, 1,2, 1,2
1Sheffield Collaboratorium for Antimicrobial Resistance and Biofilms (SCARAB), University of Sheffield, 2Department of Chemical and Biological Engineering, University of Sheffield

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The protocol describes a step-by-step method to set up an ex vivo ovine wounded skin model infected with Staphylococcus aureus. This high-throughput model better simulates infections in vivo compared with conventional microbiology techniques and presents researchers with a physiologically relevant platform to test the efficacy of emerging antimicrobials.

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High-Throughput Ex Vivo Ovine Skin Wound Model Testing Emerging Antibiotics Researchers Preclinical Stages Antimicrobial Efficacy Novel Formulations Drug Design Formulation Rapid Reproducible Results Representative Wound Environment Purpose-bred Animals Topical Antimicrobials Wound Infections Clinic Challenges Contamination Dexterity Aseptic Technique Tissue Processing Disinfection Forceps Dry Heat Sterilization Autoclave Glassware 200 PPM Chlorine Dioxide Solution Forehead Section Of The Lamp Electric Clippers Hair Removal Cream
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