Rivista
/
Neuroscienze
/
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease
JoVE Journal
Neuroscienze
È necessario avere un abbonamento a JoVE per visualizzare questo.  Accedi o inizia la tua prova gratuita.
JoVE Journal Neuroscienze
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease

DOI:
10.3791/62970-v

•

05:51 min

•

October 14, 2021

•

, ,
1Department of Translational Neuroscience, College of Human Medicine,Michigan State University, 2Hauenstein Neuroscience Center, Mercy Health Saint Mary’s

Capitoli

  • 00:04Introduction
  • 00:54Preparation of Reagents and Supplies and Cage Setup
  • 03:15Levodopa-Induced Dyskinesia Rating Post-Injection
  • 04:04Results: L-DOPA-Induced Dyskinesias (LID) Assessment in the Parkinsonian Rats
  • 05:06Conclusion

Summary

Traduzione automatica

Traduzione automatica

This article describes methods to induce and evaluate levodopa-induced dyskinesias in a rat model of Parkinson's disease. The protocol offers detailed information regarding the intensity and frequency of a range of dyskinetic behaviors, both dystonic and hyperkinetic, providing a reliable tool to test treatments targeting this unmet medical need.

Tags

Keywords: Levodopa-induced DyskinesiaParkinson’s DiseaseRat ModelInductionAssessmentRating ScaleAnimal ModelL-DOPABenserazideSubcutaneous Injection

Article

Embed

AGGIUNGI ALLA PLAYLIST

Usage Statistics

Video correlati

check_url/it/62970?article_type=v

Methods to Characterize Spontaneous and Startle-induced Locomotion in a Rotenone-induced Parkinson’s Disease Model of Drosophila
check_url/it/62970?article_type=v

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
check_url/it/62970?article_type=v

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
check_url/it/62970?article_type=v

Simple Surgical Induction of Conductive Hearing Loss with Verification Using Otoscope Visualization and Behavioral Clap Startle Response in Rat
check_url/it/62970?article_type=v

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
check_url/it/62970?article_type=v

Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson’s Disease
check_url/it/62970?article_type=v

Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis
check_url/it/62970?article_type=v

A Rat Model of EcoHIV Brain Infection
check_url/it/62970?article_type=v

The 6-hydroxydopamine Rat Model of Parkinson’s Disease
check_url/it/62970?article_type=v

Analyzing the Parkinson’s Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Read Article