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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease
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Neurosciences
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Journal JoVE Neurosciences
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease

3,330 Views

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05:51 min

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October 14, 2021

DOI:

10.3791/62970-v

DOI:
10.3791/62970-v

•

05:51 min
October 14, 2021

•

8 Views
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1Department of Translational Neuroscience, College of Human Medicine,Michigan State University, 2Hauenstein Neuroscience Center, Mercy Health Saint Mary’s

Summary

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This article describes methods to induce and evaluate levodopa-induced dyskinesias in a rat model of Parkinson's disease. The protocol offers detailed information regarding the intensity and frequency of a range of dyskinetic behaviors, both dystonic and hyperkinetic, providing a reliable tool to test treatments targeting this unmet medical need.

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Cite this Article

Caulfield, M. E., Stancati, J. A., Steece-Collier, K. Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease. J. Vis. Exp. (176), e62970, doi:10.3791/62970 (2021).

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