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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease
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JoVE Journal Neurowissenschaften
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson’s Disease

DOI:
10.3791/62970-v

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05:51 min

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October 14, 2021

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, ,
1Department of Translational Neuroscience, College of Human Medicine,Michigan State University, 2Hauenstein Neuroscience Center, Mercy Health Saint Mary’s

Kapitel

  • 00:04Introduction
  • 00:54Preparation of Reagents and Supplies and Cage Setup
  • 03:15Levodopa-Induced Dyskinesia Rating Post-Injection
  • 04:04Results: L-DOPA-Induced Dyskinesias (LID) Assessment in the Parkinsonian Rats
  • 05:06Conclusion

Summary

Automatische Übersetzung

Automatische Übersetzung

This article describes methods to induce and evaluate levodopa-induced dyskinesias in a rat model of Parkinson's disease. The protocol offers detailed information regarding the intensity and frequency of a range of dyskinetic behaviors, both dystonic and hyperkinetic, providing a reliable tool to test treatments targeting this unmet medical need.

Tags

Keywords: Levodopa-induced DyskinesiaParkinson’s DiseaseRat ModelInductionAssessmentRating ScaleAnimal ModelL-DOPABenserazideSubcutaneous Injection

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