Rivista
/
Neuroscienze
/
A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
JoVE Journal
Neuroscienze
È necessario avere un abbonamento a JoVE per visualizzare questo.  Accedi o inizia la tua prova gratuita.
JoVE Journal Neuroscienze
A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

3,016 Views

•

08:13 min

•

May 31, 2021

DOI:

10.3791/62709-v

DOI:
10.3791/62709-v

•

08:13 min
May 31, 2021

•

23 Views
, , ,
1Department of Biological Sciences,University of Notre Dame, 2Center for Zebrafish Research,University of Notre Dame, 3Center for Stem Cells and Regenerative Medicine,University of Notre Dame

Summary

Automatically generated

We modified the Marmarou weight drop model for adult zebrafish to examine a breadth of pathologies following blunt-force traumatic brain injury (TBI) and the mechanisms underlying subsequent neuronal regeneration. This blunt-force TBI model is scalable, induces a mild, moderate, or severe TBI, and recapitulates injury heterogeneity observed in human TBI.

Explore More Videos

ZebrafishBlunt-force InjuryTraumatic Brain InjuryTBIModeling ClaySteel DiscBall BearingInjury SeverityDissectionOptic NerveParietal Plate

Read Article

Cite this Article

Hentig, J., Cloghessy, K., Dunseath, C., Hyde, D. R. A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish. J. Vis. Exp. (171), e62709, doi:10.3791/62709 (2021).

Download .ris file

Copy

Share Video

.

Copy