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A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
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JoVE Revista Neurociencias
A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

3,016 Views

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08:13 min

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May 31, 2021

DOI:

10.3791/62709-v

DOI:
10.3791/62709-v

•

08:13 min
May 31, 2021

•

23 Views
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1Department of Biological Sciences,University of Notre Dame, 2Center for Zebrafish Research,University of Notre Dame, 3Center for Stem Cells and Regenerative Medicine,University of Notre Dame

Summary

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We modified the Marmarou weight drop model for adult zebrafish to examine a breadth of pathologies following blunt-force traumatic brain injury (TBI) and the mechanisms underlying subsequent neuronal regeneration. This blunt-force TBI model is scalable, induces a mild, moderate, or severe TBI, and recapitulates injury heterogeneity observed in human TBI.

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Hentig, J., Cloghessy, K., Dunseath, C., Hyde, D. R. A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish. J. Vis. Exp. (171), e62709, doi:10.3791/62709 (2021).

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