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JoVE Journal Neuroscience
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
 

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

Article DOI: 10.3791/59558-v • 08:33 min • June 25th, 2019
June 25th, 2019 •
1, 1, 1,2,3,4, 1,2
1Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, 2Neurology Department, Neurocenter of Southern Switzerland, 3Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 4Faculty of Biomedical Sciences, Università della Svizzera Italiana

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Here, we present a protocol for a free-floating indirect immunofluorescence assay on skin biopsy sections that allows for the identification of disease specific conformation variants of alpha synuclein involved in Parkinson disease and multiple proteins of the peripheral nervous system.

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Alpha Synuclein Aggregates Cutaneous Peripheral Nerve Fibers Free-floating Immunofluorescence Assay Parkinson's Disease Clinical Signs Motor Involvement Substantia Nigra Skin Biopsy Biomarker Diagnostic Purposes Cure Skin Biopsies Pathogenesis PLP Fixative Solution Sorensen's Solution
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