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In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes
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In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes
Capitoli
- 00:04Titolo
- 00:42Guide Cannula Implantation
- 04:17Microdialysis Setup
- 07:24Results: Representative Interstitial Fluid (ISF) Tau Changes Upon Picrotoxin Reverse Microdialysis
- 07:52Conclusion
In vivo microdialysis has enabled collection of molecules present in brain interstitial fluid (ISF) from awake, freely-behaving animals. In order to analyze relatively large molecules in ISF, the current article specifically focuses on the microdialysis protocol using probes with high molecular weight cut off membranes.
