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Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
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JoVE Journal Neuroscienze
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

DOI:
10.3791/52741-v

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06:30 min

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June 13, 2015

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, , , , , , , ,
1Department of Pediatrics,University of Alberta, 2Montreal Neurological Institute and Hospital,McGill University

Capitoli

  • 00:05Titolo
  • 01:27Fly Collection and Climbing Assay
  • 03:57Analysis of Fly Performance
  • 04:54Results: Climbing Deficits in a Drosophila Model of Neurodegenerative Disorders
  • 06:01Conclusion

Summary

Traduzione automatica

Traduzione automatica

We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.

Tags

Climbing DefectsDrosophila ModelNeurodegenerative DisordersLocomotive DefectsWhole Exome SequencingLocomotive FunctioningNegative Geotaxis AssayMobility DysfunctionsDrosophila MutantsLocomotion Defects

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