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神経変性疾患のショウジョウバエモデルにおけるクライミング欠陥の定量分析
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Neuroscienze
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JoVE Journal Neuroscienze
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
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神経変性疾患のショウジョウバエモデルにおけるクライミング欠陥の定量分析

18,023 Views

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06:30 min

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June 13, 2015

DOI:

10.3791/52741-v

DOI:
10.3791/52741-v

•

06:30 min
June 13, 2015

•

26 Views
, , , , , , , ,
1Department of Pediatrics,University of Alberta, 2Montreal Neurological Institute and Hospital,McGill University

Summary

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We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.

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Climbing DefectsDrosophila ModelNeurodegenerative DisordersLocomotive DefectsWhole Exome SequencingLocomotive FunctioningNegative Geotaxis AssayMobility DysfunctionsDrosophila MutantsLocomotion Defects

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Cite this Article

Madabattula, S. T., Strautman, J. C., Bysice, A. M., O’Sullivan, J. A., Androschuk, A., Rosenfelt, C., Doucet, K., Rouleau, G., Bolduc, F. Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders. J. Vis. Exp. (100), e52741, doi:10.3791/52741 (2015).

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