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Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats
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Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats
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10:44 min
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August 12, 2015
DOI:
1Interdepartmental Neuroscience Program,Yale University, 2Department of Biotechnical and Clinical Laboratory Sciences, School of Medicine and Biomedical Sciences,University at Buffalo, 3Department of Psychiatry,Yale School of Medicine, 4Department of Cellular and Molecular Physiology,Yale School of Medicine
Summary
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Rapid fluctuations in extracellular dopamine (DA) mediate both reward processing and motivated behavior in mammals. This manuscript describes the combined use of fast scan cyclic voltammetry (FSCV) and intra-oral tastant administration to determine how tastants alter rapid dopamine release in awake, freely moving rats.
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Wickham, R. J., Park, J., Nunes, E. J., Addy, N. A. Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats. J. Vis. Exp. (102), e52468, doi:10.3791/52468 (2015).
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