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In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration
JoVE Journal
Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

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14:14 min

January 06, 2014

DOI:

14:14 min
January 06, 2014

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Summary

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Neutrophil trans-epithelial migration in response to mucosal bacterial infection contributes to epithelial injury and clinical disease. An in vitro model has been developed that combines pathogen, human neutrophils, and polarized human epithelial cell layers grown on transwell filters to facilitate investigations towards unraveling the molecular mechanisms orchestrating this phenomenon.

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