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研究钝力损伤对成年斑马鱼影响的可扩展模型

Journal JoVE
Neurosciences

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Journal JoVE Neurosciences

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

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研究钝力损伤对成年斑马鱼影响的可扩展模型

3,011 Views

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08:13 min

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May 31, 2021

DOI:

10.3791/62709-v

DOI:

10.3791/62709-v

•

08:13 min

May 31, 2021

•

23 Views

James Hentig^1,2,3, Kaylee Cloghessy^1,2,3, Chloe Dunseath^2,3, David R. Hyde^1,2,3

¹Department of Biological Sciences,University of Notre Dame, ²Center for Zebrafish Research,University of Notre Dame, ³Center for Stem Cells and Regenerative Medicine,University of Notre Dame

Summary

我们修改了成年斑马鱼的Marmarou体重下降模型，以检查钝力创伤性脑损伤（TBI）后的病理范围以及随后神经元再生的机制。这种钝力 TBI 模型具有可扩展性，可诱发轻度、中度或重度 TBI，并概括在人类 TBI 中观察到的损伤异质性。

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