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In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes
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Neurosciences
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Journal JoVE Neurosciences
In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

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11:42 min

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June 10, 2021

DOI:

10.3791/62016-v

DOI:
10.3791/62016-v

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11:42 min
June 10, 2021

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1Center for Gene Therapy,The Research Institute at Nationwide Children’s Hospital, 2College of Medicine, The Ohio State University

Tags

In Vitro ModelingNeurological DiseasesFibroblastsNeuronal Progenitor CellsAstrocytesDirect ConversionSkin BiopsyRetroviral VectorsOct3/4Klf4Sox2C-MycTransductionNeurodegenerative DiseasesCell CultureCo-culturesDisease MechanismsMedication Testing

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Dennys, C. N., Sierra-Delgado, J. A., Ray, S. S., Hartlaub, A. M., Roussel, F. S., Rodriguez, Y., Meyer, K. In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes. J. Vis. Exp. (172), e62016, doi:10.3791/62016 (2021).

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